Featured in Dermascope Magazine

Annette M. Tobia, PhD and Alice Marcy, PhD

Eat wisely to look good. It’s a mantra worth remembering. Diet nourishes skin from within, and some skin conditions, such as acne and rosacea, require even more careful attention to what’s on our plate. You might not realize that certain foods and supplements actually enhance skin properties normally achieved with topical skin treatments.

 

Acne: Dietary Myths and Facts

 

Acne results from clogged pores in the skin. Sebum, the oily substance secreted by glands at the bottom of pores, mixes with dead cells to form a plug that can become infected. It is characterized by pimples–red bumps, whiteheads, blackheads, cysts, pustules and nodules. About 80 percent of people experience acne from adolescence to age 30, and it can return in an older adult after age 40. Myths persist about chocolate and fried foods causing acne, but there is limited scientific support for any link.

An analysis of 27 research studies published in 2013 examined the connection between diet and acne. The authors concluded that for 15-25 year-old males with acne, a diet with a low glycemic load resulted in a decreased number of lesions. These same authors published a subsequent questionnaire study in 2014 of 248 male and female ranging from18 to 25 years of age. The results indicated that people with moderate to severe acne reported a diet with increased glycemic index, added sugar, saturated fat, and fewer servings of fish, compared with people who had no or mild acne. Foods with a low glycemic index (see Figure) do not create sharp blood sugar spikes as they are metabolized. Excess sugar can contribute to an inflammatory state, and low glycemic foods might prevent this from happening. For conditions that are characterized by inflammation, such as acne, a low glycemic diet might be beneficial.

Then there are dairy products, which have received a high level of attention, especially in relationship to people with acne. Several retrospective studies of affected people suggest that ingestion of milk is associated with the condition. Surprisingly, skim milk in the diet has a higher association with acne than whole milk! The basis for this result is unclear, but might be due to different hormone levels in skim milk or the presence of additives in skim milk, such as whey protein. Alternatively, there may be a difference in the way whole milk is metabolized, and the presence of fat in whole milk improves absorption of a beneficial component of milk.

Clear cause and effect relationships between diet and acne have not been firmly established for all people with acne, and research studies with adults are especially scarce. There are likely to be individual dietary factors along with lifestyle circumstances, such as stress level and quality of sleep, that together impact the condition. A dietary journal can be useful to help people determine what foods are associated with increased acne breakouts.

Food Triggers of Rosacea Flare-ups

 

Rosacea is a skin condition characterized by facial redness, superficial blood vessels, inflammation, and breakouts. The cheeks, nose and forehead are commonly affected areas. As many as 4-10 percent of the US population is affected, and 75 percent are women of middle age (30-50 years old). The condition is more common among people of Northern European, English, and Irish descent, and 30-40 percent of people with rosacea have an affected family member.  Scientists are only beginning to understand the basis for rosacea; it seems to involve an imbalance of microbes that populate skin.  Although there is currently no cure, newly available prescription drug treatments have offered many people symptomatic relief.

An important part of rosacea management is awareness of circumstances and foods that can trigger a flare-up.  A characteristic of rosacea is intense facial flushing that can occur with exposure to cold or hot temperatures, or the “heat” of spicy foods. People with rosacea should wait for steaming hot food to cool before digging in, and avoid hot drinks, such as coffee, tea, hot chocolate. Other dietary triggers for flushing are alcohol, dairy products, vinegar (such as in pickled foods), citrus fruit, eggplant, and spinach.

Many of these foods contain elevated amounts of histamine, a naturally occurring neurotransmitter that causes blood vessels to expand leading to skin redness and swelling. Histamine is a flavor enhancing byproduct of fermentation, and foods such as cheese and sauerkraut tend to have high levels of the chemical. Other foods can cause the release of histamine from immune cells and produce similar symptoms to a food allergy.

People with rosacea should avoid histamine-rich foods and foods that cause histamine release (see Table). Individuals will unlikely be affected by all of these foods, and a food diary can help identify which ones are bad actors and what is the threshold amount for a reaction.

 

Examples of Histamine Rich Foods

Foods that Cause Histamine Release

Fish and shellfish- tuna, mackerel, mahi mahi, anchovy, herring, bluefish, amberjack and marlin.
Processed, smoked or fermented meats
Fermented dairy products- aged cheese, yogurt, sour cream Milk
Fruits- citrus, apricots, bananas, berries, cherries, avocados Fruits- bananas, tomatoes, strawberries, papaya, pineapple
Vegetables- spinach, eggplant, pumpkin, tomatoes tomatoes, spinach
tea
Vinegar containing foods
Seasonings-cinnamon, curry
chocolate chocolate
Beer, wine Alcohol-beer, champagne, red wine
Nuts, peanuts

Edible Sun Protection

Skin contains several chemicals that act as endogenous UV protectants and anti-oxidants. One group of chemicals, carotenoids, is made of highly effective inactivators of molecules that cause oxidative stress. Humans lack the ability to synthesize carotenoids, so they must be supplied by the diet. Carotenoids supply the red and yellow pigments in brightly colored fruits and vegetables; the most common ones in our diet are alpha- and beta-carotene (precursor to vitamin A), lycopene, beta-cryptyzanthin, lutein and zeaxanthin. Nutritional supplements of two carotenoids, beta-carotene and lycopene (red pigment in tomatoes), have been investigated for their benefits to skin. In one clinical trial, volunteers taking either a supplement with beta-carotene or a lycopene enriched diet showed protection from UV-induced redness. Such benefits for beta-carotene did not happen immediately and required an extensive, 7-week treatment period.

In a more recent double-blinded study with a group of 46 people, the skin effects after 12 weeks of treatment with dietary supplements containing the carotenoids lutein (10 mg) and zeaxanthin (2 mg) were measured. Similar to the results with beta-carotene and lycopene, treated participants showed protection from UV-induced redness compared to placebo treated volunteers. There was a two-fold increase in minimal erythemal dose (MED), which is the amount of UV exposure needed to cause sunburn in people treated with the carotenoid supplements. Volunteers taking the carotenoid supplement also showed an increase in skin firmness and self-reported an improvement in overall skin tone. The levels of lutein and zeaxanthin used for this study are comparable to the amounts in single servings of dark green leafy vegetables, such as kale, spinach, turnip greens, collards, dandelion greens, and mustard greens. 

Although the level of UV protection with carotenoid supplementation was not comparable to treatment with an SPF containing topical product, these results demonstrate that achievable dietary changes can improve skin defenses and appearance.

Timing is Everything

 

What we eat is important, but when we eat affects our health as well. Upon waking up in the morning, you might well have gone as long as 12 hours without food or drink! Chances are, your body is dehydrated and starving for nutrients! A healthy breakfast with a balance of fat, protein, and complex carbohydrates will quickly provide energy and satisfy hunger. Lunch is a great time for feasting on fruit, salad, or veggies. With busy schedules, it’s easy to skip meals or end up eating a late dinner an hour before bedtime.

A heavy evening meal just prior to bedtime is more likely to disrupt sleep patterns. Lying down after a full meal can cause acidic stomach contents to irritate the esophagus and result in heartburn. Fatty foods are especially problematic; they take an extended time to digest, and stay in the stomach longer. Caffeinated beverages, alcohol, dark chocolate, spicy foods and acidic foods–tomatoes and citrus, for example– can also produce heartburn. The effects of inadequate sleep are always visible on your face. After all, “You look tired” is often a politely coded message for, “You look old.” Avoiding heavy meals, alcohol and acidic foods at least two or three hours before bed will help ensure uninterrupted “beauty” rest.

Decreasing food intake is an excellent way to lose weight, and intermittent fasting has recently become a popular approach to a healthier lifestyle. There are various timetables for fasting: eating only during a set 8 hour period each day; fasting for 24 hours once or twice a week; and fasting for 24 hours once or twice a month.

From animal studies, it is clear that decreased caloric intake can improve longevity, decrease oxidative stress, and improve metabolism. Research has shown similar metabolic benefits for people. Although numerous followers have personal anecdotes about the skin benefits of periodic fasting, there have not been rigorous scientific studies to demonstrate measurable improvements in skin. For otherwise healthy adults, a meal pattern that incorporates fasting is easy enough to try for a period of time to see if it improves skin texture and/or appearance.

Beauty from Within

 

Skin health is a reflection of overall body health and a nutritionally sound diet, both of which are an important foundation for the best possible appearance. For some skin conditions, dietary changes can result in improvement, but set realistic expectations. The effect varies from person to person.

Sources

Burris, J., Rietker, W., and Woolf, K. (2013) Acne: The role of medical nutrition therapy. J Acad Nutr Diet 113:416-430. 

Burris, J., Rietkerk, W. and Woolf, K. (2014) Relationships of self-reported dietary factors and perceived acne severity in a cohort of New York young adults. J. Acad Nutr Diet 114(3):384-92. 

Harvie, M. and Howell A. (2017) Potential Benefits and Harms of Intermittent Energy Restriction and Intermittent Fasting Amongst Obese, Overweight and Normal Weight Subjects—A Narrative Review of Human and Animal Evidence. Behav. Sci 7(1): 4.

Juturu, V., Bowman, J.P., Deshpande, J. (2016) Overall skin tone and skin lightening-improving effects with oral supplementation of lutein and zeaxanthin isomers: a double-blind, placebo-controlled clinical trial. Clin Cosmetic & Invest Derm 9:325-332. 

Kucharska, A., Szmurto, A. and Sinska, B. (2016) Significance of diet in treated and untreated acne vulgaris. Adv Dermatol Allergol 33(2):81-86. 

LaRosa, C.L., Quach K.A., Koons, K., Kunselman, A.R., Zhu, J., Thiboutot, D.M. and Zaenglein, A.L. (2016) Consumption of dairy in teenagers with and without acne. J Acad Derm 75:318-322.

National Rosacea Society Website www.rosacea.org

Schagen, S.K., Zampeli, V.A., Makrantonaki, E. and Zouboulis, C. C. (2012) Discovering the Link Between Nutrition and Skin Aging. Dermato-Endocrinology 4(3):297-308. 

About the Authors

Annette M. Tobia, Ph.D., is CEO and founder of Dynamis Skin Science, which offers the MEG 21 skincare product line. Dr. Tobia earned her Ph.D. from New York University, and her law degree from Rutgers School of Law. She conducted postdoctoral research at Rockefeller University. 

Alice Marcy, Ph.D. is Scientific Operations Officer at Dynamis Pharmaceuticals. Dr. Marcy earned her Ph.D. from Johns Hopkins University School of Medicine.