UV Damage
Breaks down collagen and elastin. Wrinkles, sunspots, loss of elasticity.
Addressed by sunscreen
Published clinical trial
Advanced anti-glycation technology
Made in the USA
Three key drivers of skin aging
Sunscreen filters UV. Antioxidants fight free radicals. But glycation, one of the contributing factors to visible skin aging, isn't addressed by a typical routine. That's what Supplamine® is for.
Oxidative Stress
Free radicals damage cells. Dullness, uneven tone, premature aging.
Addressed by antioxidants
Glycation
Sugar reacts with collagen and elastin, forming AGEs that stiffen the fibres.
Addressed by Supplamine®
What glycation does
Glycation is one of the contributing factors to visible skin aging.
1
Supple fibres
Collagen and elastin coil and flex.
2
Sugar reacts
Over time, sugar reacts with the fibres in a multistep process called glycation.
3
Cross-links form
Some reactions create Advanced Glycation End products (AGEs), rigid cross-links that stiffen the fibres. Stiffer fibres flex less, one of several reasons skin loses firmness.
Images are for illustration purposes only.
Supplamine® helps interrupt sugar damage in two ways.
Our patented anti-glycation technology helps address reactive compounds involved in glycation, supporting healthier-looking skin over time.
Learn the science →
01
Helps Interrupt AGE Formation
Helps interfere with reactions that contribute to the formation of advanced glycation end products (AGEs).
02
Targets Reactive By-Products
Helps neutralize reactive intermediates involved in the glycation process, before they can contribute to collagen cross-linking.
Discover the Serum
Images are for illustration purposes only.
Physician-dispensedAdvanced anti-glycation technologyClinically proven results
Results that keep building.
Measured at weeks 2, 4, 6 and 8. Improving at every checkpoint.
+62.9%
Skin hydration at 8 weeks
+35.4%
Skin firmness at 8 weeks
−44.2%
Area of lines & wrinkles
−50.5%
Superficial facial lines
In an 8-week open-label study of an original MEG 21 Supplamine® formula, conducted by a contract research organisation.
See the full evidence
Before
After 28 days
Before
After 28 days
Before
After 28 days
Recommended by physicians
In their own words.
I was introduced to MEG 21 over 20 years ago. I was dazzled by the science but fell in love with how great it works. This has been my go-to product for myself, my family, and my patients.
What I love about MEG 21 is that it actually works — thanks to Supplamine®, their powerful, science-backed secret weapon. It does the heavy lifting, delivering real, visible improvements with smoother skin. No hype — just healthier, more resilient skin you can truly see and feel.
MEG 21 products are by far the best topical treatments for deep moisturizing and anti-aging effects that I have found. When I recommend MEG 21, I speak from both science and personal experience. It makes skin supple — less wrinkled, less dry, less 'hard.'
MEG 21 offers effective moisturization, addresses skin firmness and reduces fine lines and wrinkles in as little as four weeks.
What people report.
Build your routine.
Full-size routines built around Supplamine®.
4 full sizes
Complete Defense
Advanced Defense Serum, Smooth Radiance Face Treatment, Bright & Firm Eye Treatment, Daily Mineral Shield SPF 30.
2 full sizes
Day Defense
Advanced Defense Serum and Daily Mineral Shield SPF 30.
2 full sizes
Essentials Duo
Smooth Radiance Face Treatment and Bright & Firm Eye Treatment.
2 full sizes
Face & Décolleté
Smooth Radiance Face Treatment and Décolleté Treatment.
