WHERE SCIENCE MEETS SKINCARE
FROM CANCER RESEARCH TO SKINCARE BREAKTHROUGH
MEG 21 with Supplamine® began with scientific research at Fox Chase Cancer Center, where scientists were studying sugar-related damage in cancer and diabetes. They discovered it was possible to reduce the formation of AGEs — harmful compounds that accelerate aging.
Dr. Annette M. Tobia, Ph.D., saw its potential beyond medicine. Working with Fox Chase researchers, she helped develop and test the science for skincare — leading to the creation of Supplamine®, the patented compound at the heart of MEG 21.
THE PROBLEM: WHAT’S
REALLY AGING YOUR SKIN?
It’s Not Just Sun or Stress. It’s Sugar.
Excess sugar binds to proteins like collagen and elastin,
forming AGEs (Advanced Glycation End Products).
These stiffen and break down skin structure, causing:
✓ Wrinkles and sagging
✓ Dullness and uneven tone
✓ Loss of firmness
✓ Increased inflammation
THE SOLUTION: SUPPLAMINE®
A Patented Compound That Targets Glycation
Supplamine® works at the cellular level to:
✓ Neutralize toxic sugar byproducts (e.g., 3DG, CML, CEL)
✓ Reduce inflammation and oxidative stress
✓ Support collagen structure and hydration
✓ Deliver visible results without irritation or downtime
CLINICAL RESULTS
Clinically Studied. Scientifically Proven.
Over the past 25 years, MEG 21 has been rigorously evaluated in:
✓ 7+ independent clinical trials
✓ 150+ volunteers
✓ 100% showed improvement in at least one area:
• Firmness
• Hydration
• Smoothness
• Fine line reduction
Clinically tested Supplamine® formulas showed visible improvements in skin appearance within 4–8 weeks:
✓ +63% increase in skin hydration
✓ +35% improvement in firmness
✓ –43% reduction in the appearance of wrinkle depth
IN JUST 4 WEEKS*:
64%
of participants had a reduction in visual dryness
26%
saw reduce crepiness brighter, smoother skin
48%
Reduced tactile dryness
94%
said their skin looked more youthful
*Based on a 4-week clinical study with 20 participants. Individual results may vary.
REAL PEOPLE, REAL RESULTS
Before
After
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See the visible transformation from Supplamine®-powered skincare — without peeling, irritation, or downtime.
TRUSTED BY SKINCARE PROFESSIONALS
Leading dermatologists and aestheticians recommend our scientifically-proven formulations for optimal skin health.
In our cosmetic dermatology practice, the MEG 21 products are very effective moisturizers that are an important part of comprehensive skincare regimens. MEG 21’s soothing and hydrating ingredients allow the skin to tolerate what could otherwise be irritating treatments and they offer clinically validated anti- inflammatory benefits that improve the appearance of aging, sun-damaged skin.
Offer effective moisturization, as well as addresses skin firmness and reduces fine lines and wrinkles in as little as four weeks. For patients that undergo surgical procedures, MEG 21 provides improved wound healing, erythema reduction, and smoother skin texture. Even patients that are just looking for a daily moisturizer get benefits with constant use of MEG 21.
“MEG 21 products are by far the best topical treatments for deep moisturizing and anti-aging effects that I have found...When I recommend MEG 21, I speak from both science and personal experience. The patented ingredient that sets MEG 21 apart is Supplamine®, which reverses glycation caused by dietary sugars... It makes skin supple—less wrinkled, less dry– less ‘hard.’
MEG 21 with Supplamine® products are on the cutting edge of skin therapy. They uniquely and effectively address glycation, one of the most overlooked processes of skin aging. They are a great preventive treatment for the long-term damaging effects of sugar.
PROVEN OVER TIME
Trusted by Customers for Over 20 Years
For more than two decades, MEG 21 has delivered real, lasting results. Trusted by dermatologists, estheticians, and skincare users around the world, it continues to prove itself year after year.
SAFE. GENTLE. TRUSTED.
Dermatologist-Tested. Patient-Approved.
All MEG 21 products are:
✓ Dermatologist- and ophthalmologist-tested
✓ Non-irritating and fragrance-free
✓ Safe for contact lens wearers
✓ Suitable for post-procedure use
*Disclaimer: The information presented on website is for educational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. *Clinical References: References to clinical studies relate to the evaluation of ingredients or product formulations for visible skin appearance and condition. *Supplamine® is a patented compound developed for cosmetic use. Statements regarding its effects are based on in vitro studies, ingredient data, and third-party clinical evaluations of finished skincare products. *No Medical Claims: MEG 21 products are cosmetic and not drugs. They are not intended to modify the structure or function of the skin or body. *Individual Results May Vary.