MEG 21 with Supplamine® stands at the forefront of scientific innovation in skincare, addressing one of the most critical yet overlooked processes of skin aging: glycation. Originating from cancer and diabetes research at the Fox Chase Cancer Center, Supplamine® has been rigorously tested and proven effective through multiple clinical studies over the past 20 years. Our unique approach combines cutting-edge science with practical skincare solutions, making MEG 21 the most scientifically advanced anti-glycation skincare brand on the market.

Understanding Glycation
Glycation is a biological process where glucose (sugar) binds to proteins and lipids in the skin, forming advanced glycation end-products (AGEs). This process triggers oxidative stress, damaging collagen and elastin, which are essential for maintaining skin firmness and elasticity. As a result, glycation leads to the premature aging of the skin, characterized by fine lines, wrinkles, and loss of suppleness.

The Impact of Glycation
Excess glucose in skin fibers causes an internal reaction, where sugar molecules adhere to collagen and elastin proteins. Over time, this binding process creates AGEs, which make collagen rigid, reducing its ability to keep skin firm and youthful. This cumulative damage is a significant factor in the visible signs of aging.

Supplamine®: The Anti-Glycation Solution

Innovative Ingredients
Supplamine® is a proprietary and patented ingredient in MEG 21 products, specifically designed to combat glycation and its detrimental effects on the skin. The formula combines two powerful compounds:

  1. Meglumine: An amino sugar that acts as an enzyme inhibitor. Meglumine attracts the F3K enzyme, which produces toxic sugars, preventing these sugars from being made and thereby blocking the inflammation process.
  2. Arginine: A natural amino acid that neutralizes already-produced toxic sugars by binding to them. Arginine also enhances antioxidant activity, supports collagen production, improves hydration, and protects the skin barrier.

Clinical Efficacy
Supplamine® has been rigorously tested in over nine independent clinical trials involving more than 150 volunteers. These studies demonstrate that Supplamine®:

  • Reduces the appearance of fine lines and wrinkles
  • Increases skin moisture and glow
  • Improves overall skin texture, firmness, and smoothness
  • Provides noticeable results within just four weeks

One such study from September 2008 validated the efficacy of Supplamine®, highlighting its ability to reverse fine lines and wrinkles in as little as 28 days while providing a silky feel and youthful glow to the skin.

Cellular and Laboratory Studies
Our research shows that toxic sugars damage collagen in the skin. Laboratory studies confirm that Supplamine® effectively reduces these toxic sugars, leading to healthier and more youthful-looking skin.

Dual-Acting Formula
Supplamine® operates through a dual-acting mechanism:

  1. Lowers Inflammation: Associated with glycation, reducing skin damage.
  2. Inactivates Toxic Sugars: Neutralizes sugars from carbohydrate and fat-rich diets, reducing the appearance of fine lines, wrinkles, sagging, and dryness.


MEG 21 with Supplamine® represents a breakthrough in anti-glycation skincare. Backed by 20 years of research, 15 patents and patents pending, and numerous clinical studies, our products deliver scientifically validated results. Supplamine® addresses the root causes of skin aging, offering a comprehensive solution that combines innovation, scientific integrity, and proven efficacy. Experience the transformative power of MEG 21 with Supplamine® and achieve healthier, more youthful skin.