MEG 21 Décolleté Treatment Advanced Formula jar on a lilac background

MEG 21 Décolleté Treatment slide: what it does, four points beside the jar

MEG 21 Décolleté Treatment slide: real results, neck and décolleté before and after 28 days

MEG 21 Décolleté Treatment slide: how to use, warm it then press it in, with model

MEG 21 Décolleté Treatment slide: inside the formula, cream swatch with cocoa and shea butter

MEG 21 Décolleté Treatment slide: now paraben-free, cleaner without losing the cream

Rich Anti-Glycation Treatment

Décolleté Treatment Advanced Formula

Supplamine®
Physician Dispensed
Clinically studied
Post-Procedure

$150.001.7 fl oz / 50 mL

4.7 31 reviews

Our richest treatment, with the highest concentration of Supplamine® anti-glycation technology in the MEG 21 line, plus nourishing cocoa and shea butters, squalane, and evening primrose oil.

Now paraben-free. Built for dry, mature, and post-procedure skin, across face, neck, and chest.

Physician-dispensed

Supplamine® anti-glycation technology

Apply PM to clean skin, after serum and eye treatment. For very dry skin, use AM and PM.

Warm a small amount between fingers and press into face, neck, and décolleté.

First use: press the pump several times to prime it.

Dry, mature, normal-to-dry, and post-procedure skin. Richer texture, best used at night.

Built for the MEG 21 loyalist who has used this treatment for years, and for the ingredient-conscious shopper the paraben-free reformulation now reaches.

Water/Aqua/Eau, Propylene Glycol, Theobroma Cacao (Cocoa) Seed Butter, Isopropyl Myristate, Dimethicone, Methylglucamine HCl, Arginine HCl, Cetyl Alcohol, Isododecane, Butyrospermum Parkii (Shea) Butter, Glyceryl Monostearate, Steareth-21, Tocopherol, Caprylic/Capric Triglyceride, Polysorbate 80, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Squalane, Oenothera Biennis (Evening Primrose) Oil, Hydrogenated Vegetable Oil, Cetearyl Olivate, Sorbitan Olivate, Lecithin, Glycerin, Aloe Barbadensis Leaf Juice, Camellia Sinensis (Green Tea) Leaf Extract, Pentylene Glycol, Phenoxyethanol, Ethylhexylglycerin, Xanthan Gum, Disodium EDTA, Sodium Hydroxide.

Pair it with these for a full morning-to-night routine.

Results you can see, and measure

Every participant's skin was compared with its own starting point, so the change you see is the change that happened.

Measured by instrumentsHydration, firmness and lines tracked at 8 weeks.
Your skin vs. its own startEach result compares skin with its baseline.
Rich, never greasyDeep, lasting nourishment for dry skin.

Explore the science

+62.9%Skin hydrationat 8 weeks · Instrumental measurement

+35.4%Skin firmnessat 8 weeks · Measured by ballistometry

−44.2%Area of lines & wrinklesat 8 weeks · Image analysis of skin replicas

−50.5%Superficial facial linesat 8 weeks · Expert grading

In an 8-week open-label study of an original MEG 21 Supplamine® formula, conducted by a contract research organisation.

Individual results may vary.

Real skin. Real results.

28 days with the Décolleté Treatment, side by side.

28 days of daily useReal customer photos, side by side.
Neck and chestWhere skin often shows it first.

See all results

Neck1 / 2

Neck, side view2 / 2

Individual results may vary.

What's inside

Supplamine® at its highest concentration in the MEG 21 line, in our richest base of butters, oils and antioxidant green tea.

Supplamine® at the coreThe highest concentration in our line.
Rich, nourishing baseCocoa and shea butters, squalane and oils.
Fragrance-freeAnd paraben-free, gentle on delicate skin.

Explore the science

Supplamine® signature texture, conceptual illustration

Supplamine® Advanced anti-glycation technology Supplamine® is MEG 21's patented anti-glycation technology and the heart of every treatment formula. Glycation happens when sugars bond to collagen and elastin, contributing to stiffer, less supple skin. Supplamine® helps interrupt this process, so skin looks firmer, smoother and more resilient. Learn more

Botanical Lipids Nourishing softness Plant oils and butters such as jojoba oil, shea butter and cocoa butter help soften, nourish and condition skin. They replenish the skin's surface lipids, leaving it smoother, suppler and comfortable. Learn more

Fresh green tea leaves with golden extract droplets

Green Tea Extract Calming antioxidant care Green tea leaf extract (Camellia sinensis) is rich in polyphenols called catechins. These antioxidants help defend skin against environmental stressors and help calm the look of redness, bringing a soothing botanical touch to our formulas. Learn more

Vitamin E Nourishing antioxidant Vitamin E (tocopherol) is a skin-friendly antioxidant naturally present in the skin's surface lipids. It helps defend against free radicals, nourishes dry skin and helps keep formulas fresh, a quiet workhorse in four of our five products. Learn more

Aloe Vera Soothing hydration Aloe vera leaf juice and extract bring the plant's cooling, water-rich gel to our formulas. Aloe helps soothe and hydrate skin, leaving it feeling comfortable, soft and refreshed, even around the delicate eye area. Learn more

Glycerin Lasting hydration Glycerin is one of skincare's most trusted humectants and appears in all five MEG 21 formulas. It draws water into the outer layers of skin and helps keep it there, so skin feels soft, smooth and hydrated. Learn more

Images are for illustration purposes only.

See all our ingredients

How it works in the skin

Glycation shows first where skin is thinnest: the neck and chest. Supplamine®, the heart of MEG 21, helps interrupt it early.

Supplamine® at the coreOur signature anti-glycation complex.
A rich night treatmentPress into face, neck and décolleté.

Explore the science

Our anti-glycation complex intercepting sugar by-products above collagen fibres

Supplamine®Our patented anti-glycation technologyHelps interrupt glycation early, when sugars bond to collagen and elastin.Learn more

Images are for illustration purposes only.

Loved by our customers

In their own words, from customers who made it part of their nightly routine.

Loved for yearsMany have used it for years.
Smooth and comfortableRich, yet never greasy.

Trusted by physicians

Developed by Dr. Annette Tobia, PhD, and dispensed by physicians who trust it with their patients.

Physician-dispensedOffered in medical practices.
Complements your treatmentsUse between visits, once your provider says your skin is ready.

For professionals

**Dr. Betsy A.B. Greenleaf, DO**FACOOG, FACOG, FPMRS, FAAOPM, MBA
I was dazzled by the science but fell in love with how great it works. This has been my go-to product for myself, my family, and my patients.

**Dr. Adrian Manjarrez-Cortez, MD**Plastic Surgery
MEG 21 offers effective moisturization, addresses skin firmness and reduces fine lines and wrinkles…

**Dr. Kenneth Redcross, MD**Internal Medicine
What I love about MEG 21 is that it actually works — thanks to Supplamine®, their powerful, science-backed secret weapon.

**Dr. Alice McKee, MD**Family Medicine
When I recommend MEG 21, I speak from both science and personal experience. It makes skin supple — less wrinkled, less dry, less 'hard.'

Complete your routine

Your night cream works best as part of a full routine.

PM Power PairThe serum delivers, this cream locks it in overnight.
Day & Night DuoFace Treatment by day, Décolleté Treatment by night.

Shop the routine

Advanced Defense SerumPM Power PairThe serum delivers, this cream locks it in.

Smooth Radiance Face TreatmentDay & Night DuoThe lightweight cream for your mornings.

Daily Mineral Shield SPF 30 TintedEvery morningThis cream offers no sun protection. Finish with SPF.

Try MEG 21 with the Discovery Kit

Five travel sizes of the MEG 21 anti-glycation range in a custom cosmetic bag: the serum, two treatments, the eye treatment and the mineral SPF. The whole routine, before you commit to full sizes.

Shop the Discovery Kit — $30