In recent years, the medical and scientific communities have shown renewed interest in the
aging process — not just how we age, but how we might delay its effects. A recent New York Times article highlighted how metformin, a common diabetes medication, is being explored for its ability to slow systemic aging. This growing field of longevity research has brought an important but often overlooked biological process into the spotlight: glycation.
While metformin shows promise for reducing glycation inside the body, what about the skin? At MEG 21, we specialize in anti-glycation skincare — a clinically proven topical solution that directly targets one of the most harmful causes of visible skin aging.
What Is Glycation, and Why Does It Matter for Skin?
Glycation is a natural biochemical process where sugar molecules bind to proteins such as collagen and elastin. This reaction forms Advanced Glycation End Products (AGEs), which stiffen and degrade these structural proteins. The result? Fine lines, wrinkles, sagging, dullness, and a weakened skin barrier.
Think of AGEs as sugar-induced rust for your skin.
This process happens more rapidly with age, stress, UV exposure, and high-sugar diets. Glycation also promotes inflammation and oxidative stress, compounding damage over time. It is a silent contributor to skin aging, one that traditional skincare often overlooks.
How Is Supplamine Different?
Supplamine® is a patented compound developed by cancer researchers at Fox Chase Cancer Center. It combines meglumine and arginine, two molecules that work synergistically to block toxic sugar byproducts like 3-deoxyglucosone (3DG) and inhibit the FN3K enzyme that fuels AGE formation.
This isn't a cosmetic quick fix. Supplamine targets the underlying biological triggers of aging, helping to protect skin structure and restore healthier, firmer, more radiant skin.
Supplamine is designed to work deeper, where glycation starts. That makes it an ideal solution for those looking for a clinically proven anti-aging treatment that addresses aging at the source.
Clinically Proven Results: Wrinkles, Hydration, Firmness
Multiple independent clinical trials have validated the effectiveness of Supplamine in reducing the visible signs of aging:
- Up to 43% reduction in the appearance of fine lines and wrinkles
- +63% increase in skin hydration
- +35% improvement in skin firmness
These results were measured using advanced tools such as silicon replica analysis, ballistometers, and impedance meters. Even more important: the products were well-tolerated by sensitive skin, including post-procedure patients.
MEG 21 Face and Eye Treatments: Targeted Anti-Glycation Skincare
Our signature products — MEG 21 Smooth Radiance Face Treatment and MEG 21 Bright & Firm Eye Treatment — deliver high concentrations of Supplamine directly to the areas where signs of aging are most visible.
- The Face Treatment is ideal for daily use and clinically shown to reduce the appearance of wrinkles, increase hydration, and restore tone and elasticity. SHOP NOW -->
- The Eye Treatment is ophthalmologist-tested, non-irritating, and safe for use by contact lens wearers. It visibly improves puffiness, dark circles, and fine lines around the eyes. SHOP NOW -->
Both formulas are clinically tested and formulated for visible results, even on skin that is dry, stressed, or recovering from cosmetic treatments.
Why This Matters in the Age of Longevity
The New York Times article on metformin shows just how serious scientists are about delaying aging at a cellular level. While metformin targets the body’s metabolic processes, Supplamine takes that same principle and applies it to topical skincare.
Just as researchers are exploring how to block aging in organs, MEG 21 is working to reduce it in the skin — visibly and measurably.
A Smarter, Science-Based Approach to Anti-Aging
If you’re looking for more than a moisturizing cream or a trendy serum, MEG 21 offers a unique and science-backed solution. Our approach is grounded in peer-reviewed research, rigorous clinical testing, and a commitment to skin health over hype.
Whether you're building a clinical-strength routine or simply want a treatment that works beneath the surface, Supplamine can enhance your routine with its anti-glycation power.
Final Thoughts
You don’t need to take a pharmaceutical to fight aging. With MEG 21, you can begin addressing glycation topically today.
Because when you stop aging at the source, you don’t just look better — your skin functions better.
Explore MEG 21 Face and Eye Treatments