What are peptides?
Peptides are short strings of amino acids. In skin, some peptide fragments act as messengers: when collagen naturally breaks down, the fragments it leaves behind are part of how skin signals that it is time to renew. Cosmetic signal peptides are designed to mimic that kind of messaging.
The peptides in MEG 21 are lab-made for purity and consistency. Palmitoyl peptides carry a small fatty-acid tail (palmitic acid) that helps them work with the skin’s outer layer. The sh-polypeptides and sh-oligopeptides are lab-made, human-identical peptides (the “sh” stands for synthetic human), modeled on signaling proteins skin makes itself.
What peptides do for skin
In skincare, peptides help support the look of firmness and elasticity, help soften the appearance of fine lines, and help skin feel smoother and more cushioned. Palmitoyl Tetrapeptide-7 is also known for helping calm the look of redness and stress, so it pairs well with more active routines.
How it works
Signal peptides such as Palmitoyl Tripeptide-1 and Palmitoyl Tripeptide-5 are designed to support skin’s own collagen messaging. Palmitoyl Tetrapeptide-7 helps keep skin comfortable. The sh-polypeptides add a broader layer of support for skin renewal. Together they give skin several signals at once rather than relying on one.
Peptides work gradually, so consistent daily use matters more than a high single dose.
Why MEG 21 uses it
Peptides and Supplamine® are a natural pair. Peptides help support skin’s collagen messaging, while Supplamine® helps protect collagen from glycation, a sugar-related process that can make collagen stiff and less supple. In Advanced Defense Serum, peptides are one of the four pillars of SP-IV Complex™, alongside Supplamine®, ceramides and hydration. In Bright & Firm Eye Treatment, palmitoyl peptides support the delicate eye area together with caffeine, bakuchiol and niacinamide.
How to use it in your routine
For the face, apply Advanced Defense Serum after cleansing, before your cream. For the eyes, tap a small amount of Bright & Firm Eye Treatment along the orbital bone with your ring finger. Peptides pair well with almost everything, including antioxidants, hyaluronic acid and bakuchiol, so they fit any routine.
Who is it for?
Peptides suit almost every skin type, including sensitive skin, because they are gentle and well tolerated. They are a good choice if you notice fine lines, a loss of bounce, or thinner-feeling skin around the eyes, and they layer easily with other actives.






