Daily Anti-Glycation Treatment

Smooth Radiance Face Treatment

  • Supplamine®
  • Anti-Glycation
  • Clinically Studied
  • Best seller
$130.001.7 fl oz / 50 mL
5.0 2 reviews

Our clinically studied daily face treatment. Supplamine® anti-glycation technology with soothing bisabolol, in a weightless texture that layers under SPF and makeup.

Clinically studied to improve hydration and firmness and reduce the appearance of fine lines.

Physician-dispensed
Supplamine® anti-glycation technology

Apply AM to clean skin, after serum and eye treatment. Follow with SPF.

Can also be used PM for normal to combination skin.

All skin types. Ideal for combination, normal, and mildly dry skin, year-round.

The easiest place to start with MEG 21, and the cornerstone of med spa daily and post-procedure regimens.

Water (Aqua), Propylene Glycol, Cetearyl Alcohol, Cyclopentasiloxane, Glycerin, Alcohol Denat., Arginine HCl, Methylglucamine HCl, Simmondsia Chinensis (Jojoba) Seed Oil, Theobroma Cacao (Cocoa) Seed Butter, Polysorbate 60, Ceteareth-20, Aloe Barbadensis Leaf Extract, C12-15 Alkyl Benzoate, Squalene, Lecithin, Bisabolol, Dimethicone, Glyceryl Stearate SE, Cetearyl Olivate, Tocopherol, Polyacrylamide, C13-14 Isoparaffin, Xanthan Gum, Sorbitan Olivate, Polysilicone-11, Laureth-7, Dimethiconol, Disodium EDTA, Pentylene Glycol, Phenoxyethanol, Ethylhexylglycerin, Citric Acid, Sodium Hydroxide, Potassium Sorbate, Sodium Benzoate.

Pair it with these for a full morning-to-night routine.

Results you can see, and measure

Every participant's skin was compared with its own starting point, so the change you see is the change that happened.

  • Measured by instrumentsHydration, firmness and lines tracked at 8 weeks.
  • Your skin vs. its own startEach result compares skin with its baseline.
  • Comfortable every daySilky and easy to layer.
Explore the science
+62.9%Skin hydrationat 8 weeks · Instrumental measurement
+35.4%Skin firmnessat 8 weeks · Measured by ballistometry
−44.2%Area of lines & wrinklesat 8 weeks · Image analysis of skin replicas
−50.5%Superficial facial linesat 8 weeks · Expert grading

In an 8-week open-label study of an original MEG 21 Supplamine® formula, conducted by a contract research organisation.

Individual results may vary.

Real skin. Real results.

28 days with the Face Treatment, side by side.

  • 28 days of daily useReal customer photos, side by side.
  • Smile lines to crow's feetFour areas of the face.
See all results
Smile line, beforeBefore
Smile line, afterAfter 28 days
Smile line1 / 4
Crow's feet, beforeBefore
Crow's feet, afterAfter 28 days
Crow's feet2 / 4
Eye area, beforeBefore
Eye area, afterAfter 28 days
Eye area3 / 4
Forehead, beforeBefore
Forehead, afterAfter 28 days
Forehead4 / 4

Individual results may vary.

What's inside

Supplamine® leads the way, with five skin-loving ingredients that soothe, soften and keep skin comfortable.

  • Supplamine® at the coreOur signature complex, in every jar.
  • Soft, comfortable skinAloe, bisabolol and lipids soothe and soften.
  • Made for every dayLight, silky and easy to layer.
Explore the science
Face Treatment texture
Supplamine® signature texture, conceptual illustration Supplamine® Advanced anti-glycation technology Supplamine® is MEG 21's patented anti-glycation technology and the heart of every treatment formula. Glycation happens when sugars bond to collagen and elastin, contributing to stiffer, less supple skin. Supplamine® helps interrupt this process, so skin looks firmer, smoother and more resilient. Learn more
Golden vitamin E oil droplets Vitamin E Nourishing antioxidant Vitamin E (tocopherol) is a skin-friendly antioxidant naturally present in the skin's surface lipids. It helps defend against free radicals, nourishes dry skin and helps keep formulas fresh, a quiet workhorse in four of our five products. Learn more Fresh aloe vera leaf with clear gel Aloe Vera Soothing hydration Aloe vera leaf juice and extract bring the plant's cooling, water-rich gel to our formulas. Aloe helps soothe and hydrate skin, leaving it feeling comfortable, soft and refreshed, even around the delicate eye area. Learn more Botanical oils and butters Botanical Lipids Nourishing softness Plant oils and butters such as jojoba oil, shea butter and cocoa butter help soften, nourish and condition skin. They replenish the skin's surface lipids, leaving it smoother, suppler and comfortable. Learn more Chamomile flowers, a representative botanical for bisabolol Bisabolol Calming comfort Bisabolol is a soothing compound best known from chamomile. It helps calm the look of redness and helps skin feel comfortable, making it a gentle companion to the active ingredients in our Face Treatment and SPF. Learn more Clear glycerin droplets Glycerin Lasting hydration Glycerin is one of skincare's most trusted humectants and appears in all five MEG 21 formulas. It draws water into the outer layers of skin and helps keep it there, so skin feels soft, smooth and hydrated. Learn more

Images are for illustration purposes only.

See all our ingredients

Loved by our customers

In their own words, from customers who made it part of their daily routine.

  • Loved for the textureSilky and hydrating, never heavy.
  • An everyday favouritePart of their daily routine.
Read more stories
Face Treatment texture
Removes the tight feeling of undernourished skin and reduces wrinkles. My skin feels plump. Of all my skin products, this is the one I would greatly miss and consider my most essential!
LeahReview on meg21.com
Have used Meg 21 products for years, but just found it online. Ordered this for my face. Love the texture and the hydrated feeling. I feel as though my skin actually drinks this product in. I would highly recommend it!
ChristinaReview on meg21.com
Considering the largest organ in our body is our skin, it is imperative to treat it well. I have been using MEG 21 for years & it is my Go To nightly moisturizer! My skin feels amazing - Yes, smooth & radiant!!!
Ellie W.Review on meg21.com

Trusted by physicians

Developed by Dr. Annette Tobia, PhD, and dispensed by physicians who trust it with their patients.

  • Physician-dispensedOffered in medical practices.
  • Complements your treatmentsUse between visits, once your provider says your skin is ready.
For professionals
Dr. Betsy A.B. Greenleaf, DO
Dr. Betsy A.B. Greenleaf, DOFACOOG, FACOG, FPMRS, FAAOPM, MBA
I was dazzled by the science but fell in love with how great it works. This has been my go-to product for myself, my family, and my patients.
Dr. Adrian Manjarrez-Cortez, MD
Dr. Adrian Manjarrez-Cortez, MDPlastic Surgery
MEG 21 offers effective moisturization, addresses skin firmness and reduces fine lines and wrinkles…
Dr. Kenneth Redcross, MD
Dr. Kenneth Redcross, MDInternal Medicine
What I love about MEG 21 is that it actually works — thanks to Supplamine®, their powerful, science-backed secret weapon.
Dr. Alice McKee, MD
Dr. Alice McKee, MDFamily Medicine
When I recommend MEG 21, I speak from both science and personal experience. It makes skin supple — less wrinkled, less dry, less 'hard.'

Complete your routine

Your morning cream, with the pairings we recommend around it.

  • Daily Defense PairAdvanced Defense Serum first, then this treatment.
  • Day & Night DuoFace Treatment by day, Décolleté Treatment by night.
Shop the routine
Advanced Defense SerumDaily Defense PairApply the serum first, then this treatment.
$175.00
Peptide Bright & Firm Eye TreatmentBefore this stepFor the thinnest skin on the face.
$85.00
Daily Mineral Shield SPF 30 TintedEvery morningThis treatment offers no sun protection. Finish with SPF.
$60.00

Try MEG 21 with the Discovery Kit

Five travel sizes of the MEG 21 anti-glycation range in a custom cosmetic bag: the serum, two treatments, the eye treatment and the mineral SPF. The whole routine, before you commit to full sizes.

Shop the Discovery Kit — $30