SP-IV Complex™
Advanced Defense Serum
- SP-IV Complex™
- Peptides
- Ceramides
- Paraben free
Advanced Defense Serum is the most complete expression of MEG 21, built on SP-IV Complex™: Supplamine® anti-glycation technology, peptides, ceramides, and deep hydration in one daily formula.
Physician-dispensed
Supplamine® anti-glycation technology
Water (Aqua), Glycerin, Butylene Glycol, Propanediol, Acetyl Glutamine, Bacillus/Folic Acid Ferment Filtrate Extract, Caprylyl Glycol, Lecithin, Phenoxyethanol, Polysorbate 20, Sodium Hyaluronate, Sodium Lauroyl Lactylate, Carbomer, Ethylhexylglycerin, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1, sh-Polypeptide-11, sh-Polypeptide-9, sh-Oligopeptide-2, sh-Oligopeptide-1, sh-Polypeptide-1, Ceramide NP, Methylglucamine HCl, Arginine HCl, Phytosphingosine, Ceramide AP, Xanthan Gum, Cholesterol, Ceramide EOP.
Pair it with these for a full morning-to-night routine.
How it works in the skin
Supplamine® is the heart of MEG 21. In this serum it works alongside peptides, ceramides and hyaluronic acid, each with its own job in the skin.
- Supplamine® at the coreOur signature anti-glycation complex.
- SP-IV Complex™Four actions in one daily serum.
- Gentle every dayFragrance-free, for all skin types.
What's inside
SP-IV Complex™ brings four pillars together: Supplamine®, peptides, ceramides and hyaluronic acid, in one lightweight daily serum.
- Supplamine® at the coreOur signature complex, in every bottle.
- Barrier-loving ceramidesHelp skin hold on to moisture.
- Paraben-freeFragrance-free and easy to layer.
Multi-Peptide Complex
Firmer, smoother-looking skin
Peptides are short chains of amino acids, the components that make up skin proteins. Our formulas pair signal peptides such as palmitoyl tetrapeptide-7 and palmitoyl tripeptide-1 to help support skin that looks firmer and smoother, with a more refined texture.
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Ceramide Complex
Skin barrier support
Ceramides are lipids that naturally hold skin cells together, like mortar between bricks. Advanced Defense Serum combines three ceramides (NP, AP and EOP) with phytosphingosine and cholesterol to help reinforce the skin barrier and help skin hold on to moisture.
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Hyaluronic Acid
Hydration and plumpness
Hyaluronic acid is a moisture-binding molecule found naturally in skin. In its sodium hyaluronate form, it draws water into the outer layers of skin, helping it look plumper and smoother, with fine lines caused by dryness looking softened.
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Glycerin
Lasting hydration
Glycerin is one of skincare's most trusted humectants and appears in all five MEG 21 formulas. It draws water into the outer layers of skin and helps keep it there, so skin feels soft, smooth and hydrated.
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Images are for illustration purposes only.
Loved by MEG 21 customers
Supplamine® is at the heart of every MEG 21 formula. Here is what long-time customers say about theirs.
- Loyal for yearsMany have used MEG 21 for years.
- Recommended by professionalsOften first suggested by their esthetician or dermatologist.
Trusted by physicians
Developed by Dr. Annette Tobia, PhD, and dispensed by physicians who trust it with their patients.
- Physician-dispensedOffered in medical practices.
- Complements your treatmentsUse between visits, once your provider says your skin is ready.
I was dazzled by the science but fell in love with how great it works. This has been my go-to product for myself, my family, and my patients.
MEG 21 offers effective moisturization, addresses skin firmness and reduces fine lines and wrinkles…
What I love about MEG 21 is that it actually works — thanks to Supplamine®, their powerful, science-backed secret weapon.
When I recommend MEG 21, I speak from both science and personal experience. It makes skin supple — less wrinkled, less dry, less 'hard.'
Complete your routine
Serum first, then layer these. The pairings we recommend with it.
- The Peptide DuoWith Eye Treatment: one peptide family, face and eyes.
- Morning to nightFace Treatment by day, SPF every morning.
Try MEG 21 with the Discovery Kit
Five travel sizes of the MEG 21 anti-glycation range in a custom cosmetic bag: the serum, two treatments, the eye treatment and the mineral SPF. The whole routine, before you commit to full sizes.
Shop the Discovery Kit — $30