Your questions, answered

MEG 21 is physician-dispensed anti-glycation skincare, developed by Dr. Annette Tobia, PhD. It is recommended and dispensed in physician practices and med spas, and you can shop it right here.

Supplamine® is our patented anti-glycation technology, and it is in our serum and our Face, Décolleté and Eye treatments. It helps interrupt glycation, the process where sugar binds to collagen and elastin and stiffens them over time. Read the science.

Sugar reacts with collagen and elastin and forms rigid cross-links. Stiffer fibres flex less, one of several reasons skin loses firmness. Sunscreen covers UV and antioxidants cover oxidative stress; Supplamine® is there for glycation.

Our serum and treatments: Advanced Defense Serum, Smooth Radiance Face Treatment, Décolleté Treatment Advanced Formula and Bright & Firm Eye Treatment. Daily Mineral Shield SPF 30 is your daytime protection step.

Our Daily Mineral Shield SPF 30 is pure mineral sun protection, without Supplamine®.

Yes. A published randomized controlled trial and eight clinical studies, all on human subjects. See the science, or email professional@meg21.com for research and references.

Cleanse, then serum, then eye treatment, then your treatment cream. In the morning, finish with Daily Mineral Shield SPF 30.

Less than you think: two to three drops of serum, a pea-sized amount of Face Treatment, a small amount of Eye Treatment, and a little Décolleté warmed between your fingers.

Serum and Eye Treatment: morning and night. Face Treatment: every morning, and at night too for normal to combination skin. Décolleté: at night, or morning and night for very dry skin. Every product page has a How to use tab.

Yes. Those work on cell turnover, oxidative stress and UV. MEG 21 focuses on glycation, a separate driver of skin aging, so it adds to your routine rather than replacing anything.

No. Sun protection comes from Daily Mineral Shield SPF 30, your last step every morning.

Try the Anti-Glycation Discovery Kit: five travel sizes, the whole routine, before you commit to full sizes.

In the clinical study, results were measurable from week 2 and kept improving through week 8. Use your treatments every day and judge your skin at eight weeks.

In an 8-week open-label study of an original MEG 21 Supplamine® formula, conducted by a contract research organisation: skin hydration +62.9%, firmness +35.4%, area of lines & wrinkles −44.2% and superficial facial lines −50.5%. Individual results may vary.

No adverse events were reported in the facial study. If your skin is very reactive, try a small amount on one area first.

Décolleté Treatment Advanced Formula, our richest cream, with the highest concentration of Supplamine®. For very dry skin, use it morning and night.

Smooth Radiance Face Treatment is the lighter daily cream, made for normal to combination skin. Advanced Defense Serum suits all skin types.

Bright & Firm Eye Treatment is ophthalmologist-tested and suitable for contact-lens wearers. Pat a small amount along the orbital bone with your ring finger.

On every product page, and on our Ingredients page.

Yes. MEG 21 complements your treatments. Use it between treatments, once your provider says your skin is ready, and always follow their post-care instructions first.

Once your provider says your skin is ready. Your provider knows your treatment, so their timing comes first.

MEG 21 is dispensed in physician practices and med spas. Ask your provider, or shop online here any time.

MEG 21 is cosmetic skincare. It supports skin hydration and the look of firmness, and it is not a medicine or a treatment for medication side effects.

Please talk to your doctor about your medication and any changes you notice in your skin. They know you best.

Please ask your doctor before starting any new skincare while pregnant or breastfeeding. Every product page lists the full ingredients, so you can share them with your doctor.

Ask your doctor or dermatologist before adding MEG 21. Our products are cosmetic skincare, not medicines.

For now we deliver within the United States only. Orders usually ship within two business days after you place them; delivery times vary with your location and the shipping method you choose.

Yes, free ground shipping on US orders of $150 or more.

Because our products are skincare, all sales are final. If anything arrives damaged, defective or is not what you ordered, email info@meg21.com right away and we will make it right.

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Email info@meg21.com or use our contact form. We are happy to help.