Complete Anti-Glycation Routine
Complete Defense
- 4 Full Sizes
- Supplamine®
- Morning & Night
- Physician Dispensed
The full MEG 21 anti-glycation routine in four full sizes: Advanced Defense Serum, Bright & Firm Eye Treatment, Smooth Radiance Face Treatment and Daily Mineral Shield SPF 30 Tinted. Morning and night, start to finish.
Physician-dispensed
Supplamine® anti-glycation technology
Advanced Defense Serum
Water (Aqua), Glycerin, Butylene Glycol, Propanediol, Acetyl Glutamine, Bacillus/Folic Acid Ferment Filtrate Extract, Caprylyl Glycol, Lecithin, Phenoxyethanol, Polysorbate 20, Sodium Hyaluronate, Sodium Lauroyl Lactylate, Carbomer, Ethylhexylglycerin, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1, sh-Polypeptide-11, sh-Polypeptide-9, sh-Oligopeptide-2, sh-Oligopeptide-1, sh-Polypeptide-1, Ceramide NP, Methylglucamine HCl, Arginine HCl, Phytosphingosine, Ceramide AP, Xanthan Gum, Cholesterol, Ceramide EOP.
Bright & Firm Eye Treatment
Water (Aqua), Glycerin, Aloe Barbadensis Leaf Juice, Aloe Barbadensis Extract, Butylene Glycol, Cetearyl Alcohol, Cocos Nucifera (Coconut) Oil, Simmondsia Chinensis (Jojoba) Seed Oil, Polysorbate 60, Niacinamide, Arginine HCl, Methylglucamine HCl, Hamamelis Virginiana (Witch Hazel) Water, Persea Gratissima (Avocado) Oil, Vitis Vinifera (Grape) Seed Oil, Stearic Acid, Sodium Ascorbyl Phosphate, Caffeine, Sodium Polyacrylate, Polysorbate 20, Phenoxyethanol, Salix Alba (Willow) Bark Extract, Hydrolyzed Silk, Melia Azadirachta Seed Oil, Rosmarinus Officinalis (Rosemary) Leaf Extract, Helianthus Annuus (Sunflower) Seed Oil, Tocopherol, Tetrasodium Glutamate Diacetate, Xanthan Gum, Alcohol, Hydrolyzed Rice Bran Protein, Oxidoreductases, Lecithin, Bakuchiol, Carbomer, Pentylene Glycol, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1, Glycine Soja (Soybean) Protein, Palmitoyl Tripeptide-5, Sodium Hyaluronate, Camellia Sinensis Leaf Extract, Glycyrrhiza Glabra (Licorice) Root Extract, Potassium Sorbate, Sodium Benzoate, Sodium Hydroxide, Citric Acid.
Smooth Radiance Face Treatment
Water (Aqua), Propylene Glycol, Cetearyl Alcohol, Cyclopentasiloxane, Glycerin, Alcohol Denat., Arginine HCl, Methylglucamine HCl, Simmondsia Chinensis (Jojoba) Seed Oil, Theobroma Cacao (Cocoa) Seed Butter, Polysorbate 60, Ceteareth-20, Aloe Barbadensis Leaf Extract, C12-15 Alkyl Benzoate, Squalene, Lecithin, Bisabolol, Dimethicone, Glyceryl Stearate SE, Cetearyl Olivate, Tocopherol, Polyacrylamide, C13-14 Isoparaffin, Xanthan Gum, Sorbitan Olivate, Polysilicone-11, Laureth-7, Dimethiconol, Disodium EDTA, Pentylene Glycol, Phenoxyethanol, Ethylhexylglycerin, Citric Acid, Sodium Hydroxide, Potassium Sorbate, Sodium Benzoate.
Daily Mineral Shield SPF 30 Tinted
Active Ingredients: Titanium Dioxide 4.2%, Zinc Oxide 6.0%.
Inactive Ingredients: Water (Aqua), Cyclopentasiloxane, Caprylic/Capric Triglyceride, Glycerin, Cetyl PEG/PPG-10/1 Dimethicone, Polyglyceryl-4 Isostearate, Hexyl Laurate, Cera Alba (Beeswax), Butylene Glycol, Polyhydroxystearic Acid, PEG-30 Dipolyhydroxystearate, Sodium Chloride, Disodium Stearoyl Glutamate, Aluminum Hydroxide, Tocopheryl Acetate (Vitamin E), Camellia Sinensis (Green Tea) Leaf Extract, Aloe Barbadensis Leaf Juice, Panthenol, Bisabolol, Sodium Hyaluronate, Phenoxyethanol, Ethylhexylglycerin, Iron Oxides (CI 77491, CI 77492, CI 77499), Fragrance.
Results you can see, and measure
Every participant's skin was compared with its own starting point, so the change you see is the change that happened.
- Measured by instrumentsHydration, firmness and lines tracked at 8 weeks.
- Your skin vs. its own startEach result compares skin with its baseline.
- Every step, full sizeThe whole routine, built around Supplamine®.
+62.9%Skin hydrationat 8 weeks · Instrumental measurement
+35.4%Skin firmnessat 8 weeks · Measured by ballistometry
−44.2%Area of lines & wrinklesat 8 weeks · Image analysis of skin replicas
−50.5%Superficial facial linesat 8 weeks · Expert grading
In an 8-week open-label study of an original MEG 21 Supplamine® formula, conducted by a contract research organisation.
Individual results may vary.
Real skin. Real results.
28 days with MEG 21, side by side.
- 28 days of daily useReal customer photos, side by side.
- Face, neck and chestReal customer photos from across the routine.
Before
After 28 daysSmile line1 / 6
Before
After 28 daysCrow's feet2 / 6
Before
After 28 daysEye area3 / 6
Before
After 28 daysForehead4 / 6
Before
After 28 daysNeck5 / 6
Before
After 28 daysNeck, side view6 / 6
Individual results may vary.
How it works in the skin
Supplamine® is the heart of MEG 21 and of every treatment in your routine. Each product brings its own supporting ingredients, so the steps work together.
- Supplamine® at the coreOur signature anti-glycation complex.
- Made to work togetherEach step has its own job.
- Morning and nightYour order is in the How to use tab.
What's in your routine
Every product in full size, in the order it goes on. Tap any one to see it on its own.
- Full sizesThe same products sold on their own.
- In orderLighter textures first, richer ones after.
- Supplamine® in every treatmentOur patented anti-glycation technology.
Advanced Defense SerumStep 1 · Morning and nightOur flagship serum: Supplamine® with peptides, ceramides and hyaluronic acid in SP-IV Complex™.See product 
Bright & Firm Eye TreatmentStep 2 · Morning and nightPeptides, caffeine and niacinamide with Supplamine®, for the thinnest skin on the face.See product 
Smooth Radiance Face TreatmentStep 3 · Morning and nightThe daily treatment with Supplamine® and bisabolol. Light enough for SPF and makeup.See product 
Daily Mineral Shield SPF 30 TintedStep 4 · Every morning100% mineral broad-spectrum SPF 30, tinted with iron oxides. Always the last step.See product Loved by MEG 21 customers
Here is what long-time customers say about the products in your routine.
- Loyal for yearsMany have used MEG 21 for years.
- Recommended by professionalsOften first suggested by their esthetician or dermatologist.
Trusted by physicians
Developed by Dr. Annette Tobia, PhD, and dispensed by physicians who trust it with their patients.
- Physician-dispensedOffered in medical practices.
- Complements your treatmentsUse between visits, once your provider says your skin is ready.
I was dazzled by the science but fell in love with how great it works. This has been my go-to product for myself, my family, and my patients.
MEG 21 offers effective moisturization, addresses skin firmness and reduces fine lines and wrinkles…
What I love about MEG 21 is that it actually works — thanks to Supplamine®, their powerful, science-backed secret weapon.
When I recommend MEG 21, I speak from both science and personal experience. It makes skin supple — less wrinkled, less dry, less 'hard.'
Try MEG 21 with the Discovery Kit
Five travel sizes of the MEG 21 anti-glycation range in a custom cosmetic bag: the serum, two treatments, the eye treatment and the mineral SPF. The whole routine, before you commit to full sizes.
Shop the Discovery Kit — $30