Day & Night Anti-Glycation Routine
Face & Décolleté
- 2 Full Sizes
- Supplamine®
- Day & Night
- Neck & Chest
The Day & Night Duo. Smooth Radiance Face Treatment by day, light enough to wear under SPF and makeup, and Décolleté Treatment Advanced Formula by night, our richest cream with the most Supplamine® in the line, for face, neck and chest.
Physician-dispensed
Supplamine® anti-glycation technology
Smooth Radiance Face Treatment
Water (Aqua), Propylene Glycol, Cetearyl Alcohol, Cyclopentasiloxane, Glycerin, Alcohol Denat., Arginine HCl, Methylglucamine HCl, Simmondsia Chinensis (Jojoba) Seed Oil, Theobroma Cacao (Cocoa) Seed Butter, Polysorbate 60, Ceteareth-20, Aloe Barbadensis Leaf Extract, C12-15 Alkyl Benzoate, Squalene, Lecithin, Bisabolol, Dimethicone, Glyceryl Stearate SE, Cetearyl Olivate, Tocopherol, Polyacrylamide, C13-14 Isoparaffin, Xanthan Gum, Sorbitan Olivate, Polysilicone-11, Laureth-7, Dimethiconol, Disodium EDTA, Pentylene Glycol, Phenoxyethanol, Ethylhexylglycerin, Citric Acid, Sodium Hydroxide, Potassium Sorbate, Sodium Benzoate.
Décolleté Treatment Advanced Formula
Water/Aqua/Eau, Propylene Glycol, Theobroma Cacao (Cocoa) Seed Butter, Isopropyl Myristate, Dimethicone, Methylglucamine HCl, Arginine HCl, Cetyl Alcohol, Isododecane, Butyrospermum Parkii (Shea) Butter, Glyceryl Monostearate, Steareth-21, Tocopherol, Caprylic/Capric Triglyceride, Polysorbate 80, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Squalane, Oenothera Biennis (Evening Primrose) Oil, Hydrogenated Vegetable Oil, Cetearyl Olivate, Sorbitan Olivate, Lecithin, Glycerin, Aloe Barbadensis Leaf Juice, Camellia Sinensis (Green Tea) Leaf Extract, Pentylene Glycol, Phenoxyethanol, Ethylhexylglycerin, Xanthan Gum, Disodium EDTA, Sodium Hydroxide.
Results you can see, and measure
Every participant's skin was compared with its own starting point, so the change you see is the change that happened.
- Measured by instrumentsHydration, firmness and lines tracked at 8 weeks.
- Your skin vs. its own startEach result compares skin with its baseline.
- Every step, full sizeThe whole routine, built around Supplamine®.
+62.9%Skin hydrationat 8 weeks · Instrumental measurement
+35.4%Skin firmnessat 8 weeks · Measured by ballistometry
−44.2%Area of lines & wrinklesat 8 weeks · Image analysis of skin replicas
−50.5%Superficial facial linesat 8 weeks · Expert grading
In an 8-week open-label study of an original MEG 21 Supplamine® formula, conducted by a contract research organisation.
Individual results may vary.
Real skin. Real results.
28 days with MEG 21, side by side.
- 28 days of daily useReal customer photos, side by side.
- Face, neck and chestReal customer photos from across the routine.
Before
After 28 daysSmile line1 / 6
Before
After 28 daysCrow's feet2 / 6
Before
After 28 daysEye area3 / 6
Before
After 28 daysForehead4 / 6
Before
After 28 daysNeck5 / 6
Before
After 28 daysNeck, side view6 / 6
Individual results may vary.
How it works in the skin
Supplamine® is the heart of MEG 21 and of every treatment in your routine. Each product brings its own supporting ingredients, so the steps work together.
- Supplamine® at the coreOur signature anti-glycation complex.
- Made to work togetherEach step has its own job.
- Morning and nightYour order is in the How to use tab.
BisabololIn the Face TreatmentHelps calm the look of redness and keeps skin comfortable.Learn more 
Botanical LipidsIn the Décolleté TreatmentShea and cocoa butters soften and nourish face, neck and chest.Learn more 
Aloe VeraIn both treatmentsSoothes and hydrates, leaving skin soft and comfortable.Learn more Images are for illustration purposes only.
What's in your routine
Every product in full size, in the order it goes on. Tap any one to see it on its own.
- Full sizesThe same products sold on their own.
- In orderLighter textures first, richer ones after.
- Supplamine® in every treatmentOur patented anti-glycation technology.
Loved by MEG 21 customers
Here is what long-time customers say about the products in your routine.
- Loyal for yearsMany have used MEG 21 for years.
- Recommended by professionalsOften first suggested by their esthetician or dermatologist.
Trusted by physicians
Developed by Dr. Annette Tobia, PhD, and dispensed by physicians who trust it with their patients.
- Physician-dispensedOffered in medical practices.
- Complements your treatmentsUse between visits, once your provider says your skin is ready.
I was dazzled by the science but fell in love with how great it works. This has been my go-to product for myself, my family, and my patients.
MEG 21 offers effective moisturization, addresses skin firmness and reduces fine lines and wrinkles…
What I love about MEG 21 is that it actually works — thanks to Supplamine®, their powerful, science-backed secret weapon.
When I recommend MEG 21, I speak from both science and personal experience. It makes skin supple — less wrinkled, less dry, less 'hard.'
Try MEG 21 with the Discovery Kit
Five travel sizes of the MEG 21 anti-glycation range in a custom cosmetic bag: the serum, two treatments, the eye treatment and the mineral SPF. The whole routine, before you commit to full sizes.
Shop the Discovery Kit — $30