Supplamine® Hand Cream

Age Defying Hand Treatment

Supplamine®
Deep Hydration
Softening
Everyday Hands

$39.003.4 oz / 96 g

4.6 75 reviews

Our Age-Defying Hand Treatment powered by Supplamine® prevents hands from broadcasting age. It is ideal for repairing dryness caused by sanitizers and overwashing.
Clinically proven to combat top-of-hand skin wrinkling and dark spots and to reduce irritation, increase hydration, protect, and soften skin.

(3.4 oz / 96 g)

Physician-dispensed

Supplamine® anti-glycation technology

Massage into clean, dry hands whenever they need it, especially after washing or using sanitizer.

Give the backs of your hands extra attention, and add SPF when they'll see the sun.

All skin types.

Made for hands that feel dry from frequent washing and sanitizer, and for anyone who wants softer, smoother-looking hands.

Water, Butyrospermum Parkii Butter, Isopropyl Myristate, Lecithin, Sorbitan Stearate, Arginine HCl, Behenyl Alcohol, Cyclopentasiloxane, Dimethicone, Methylglucamine HCl, Simmondsia Chinensis Seed Oil, Theobroma Cacao Seed Butter, Glyceryl Stearate, PEG-100 Stearate, Polysorbate 80, Pentylene Glycol, Cyclohexasiloxane, Oenothera Biennis Oil, PEG-8 Dimethicone, Tocopheryl Acetate, Aloe Barbadensis Leaf Extract, Bisabolol, Canola Oil, Caprylyl Glycol, Magnesium Aluminum Silicate, PEG-40 Stearate, Triethanolamine, Caprylic/Capric Triglyceride, Citrus Limon Peel Extract, Xanthan Gum, Polyacrylamide, Acetylated Lanolin Alcohol, Cetyl Acetate, Hydroxyethylcellulose, Hexylene Glycol, C13-14 Isoparaffin, Disodium EDTA, Laureth-7, BHT, Phenoxyethanol, Diazolidinyl Urea, Iodopropynyl Butylcarbamate, Limonene, Citral

Pair it with these for a full morning-to-night routine.

How it works in the skin

Supplamine® is the heart of every MEG 21 formula, this original one included. It helps interrupt glycation early, where sugars bond to collagen and elastin.

Supplamine® at the coreOur signature anti-glycation complex.
The original formulaThe MEG 21 customers have used for years.

Explore the science

Our anti-glycation complex intercepting sugar by-products above collagen fibres

Supplamine®Our anti-glycation technologyHelps interrupt glycation early, when sugars bond to collagen and elastin.Learn more

Images are for illustration purposes only.

Trusted by physicians

Developed by Dr. Annette Tobia, PhD, and dispensed by physicians who trust it with their patients.

Physician-dispensedOffered in medical practices.
Complements your treatmentsUse between visits, once your provider says your skin is ready.

For professionals

**Dr. Betsy A.B. Greenleaf, DO**FACOOG, FACOG, FPMRS, FAAOPM, MBA
I was dazzled by the science but fell in love with how great it works. This has been my go-to product for myself, my family, and my patients.

**Dr. Adrian Manjarrez-Cortez, MD**Plastic Surgery
MEG 21 offers effective moisturization, addresses skin firmness and reduces fine lines and wrinkles…

**Dr. Kenneth Redcross, MD**Internal Medicine
What I love about MEG 21 is that it actually works — thanks to Supplamine®, their powerful, science-backed secret weapon.

**Dr. Alice McKee, MD**Family Medicine
When I recommend MEG 21, I speak from both science and personal experience. It makes skin supple — less wrinkled, less dry, less 'hard.'

Try MEG 21 with the Discovery Kit

Five travel sizes of the MEG 21 anti-glycation range in a custom cosmetic bag: the serum, two treatments, the eye treatment and the mineral SPF. The whole routine, before you commit to full sizes.

Shop the Discovery Kit — $30