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Meg 21 with Supplamine®

Bright & Firm Eye Treatment

Bright & Firm Eye Treatment

$85.00
$85.00
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Shipping calculated at checkout.

This powerful under-eye anti-aging treatment powered by Supplamine® firms, brightens, and soothes the delicate eye area. Clinically proven to diminish the appearance of fine lines, crow's feet, puffiness, and wrinkles around and under the eyes while gradually reducing the appearance of dark circles.

In an ophthalmologist-conducted study, its efficacy was proven.
Non-irritating for even sensitive eyes and contact lens wearers.

 (0.5 oz)

How to use

Apply twice daily to skin adjacent to and beneath the eye area after cleansing.

Benefits

✓ Clinically shown to reduce the appearance of fine lines, puffiness, and dark circles.

✓ Powered by Supplamine®, a patented anti-glycation compound that helps protect skin from sugar-induced aging.

✓ Helps improve skin firmness and elasticity around the delicate eye area.

✓ Supports hydration and barrier function for smoother, healthier-looking skin.

✓ Ophthalmologist-tested and safe for sensitive skin and contact lens wearers.

✓ Ideal for post-procedure use or stressed, dry, or aging skin.

✓ Targets visible signs of aging caused by glycation, inflammation, and oxidative stress.

✓ Designed to work beneath the surface, helping to preserve collagen and elastin.

✓ Inspired by longevity science and grounded in clinical testing.

Key ingredients

  • Supplamine®: Patented ingredient to intercept and reverse glycation, inflammation and metabolic oxidation caused by 3DG sugars in the skin
  • Hydrolyzed Wheat Protein: water binding agent; smooths lines; minimizes pores
  • Pfaffia Paniculata or Suma Root: source of allantoin, vitamins A, E, K and essential B vitamins for healing, cellular integrity, anti-inflammatory and antioxidant; increases microcirculation
  • Shea Butter: natural antioxidant rich emollient
  • Titanium Dioxide: brightener; UV absorption
  • Lilly Flower Extract: antioxidant; moisture retent

Ingredients

Water (Aqua), Pentylene Glycol, Cyclopentasiloxane, Caprylic/Capric Triglyceride, Arginine HCL, Methylglucamine HCL, Ethylhexyl Palmitate, Phosphatidylcholine, Steareth-21, Dimethicone, Cetearyl Alcohol, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Magnesium Aluminum Silicate, Polyamide-5, PEG-40 Hydrogenated Castor Oil, Butyrospermum Parkii (Shea Butter), Palmitoyl Hydrolyzed Wheat Protein, Ptychopetalum Olacoides Bark/Stem Extract, Pfaffia Paniculata Root Extract, Lilium Candidum Flower Extract, Aminopropyl Dimethicone, 1,2-Hexanediol, Butylene Glycol, Ceteareth-20, Isohexadecane, Polysorbate 60, Sodium Benzoate, Potassium Sorbate, PEG-100 Stearate, Butyl Alcohol, BHT, Caprylyl Glycol, Chlorphenesin, Steareth-2, Titanium Dioxide, Xanthan Gum, Disodium EDTA, Fragrance.

View full details

  • Supplamine®

    Our patented ingredient to intercept and reverse glycation, inflammation, and oxidative stress caused by the FN3K enzyme and 3DG sugars in the skin.

  • Pfaffia Paniculota + Shea Butter

    Pfaffia (Suma Root) delivers antioxidant and vitamin-rich support to enhance healing, microcirculation, and skin resilience. Paired with Shea Butter, a natural emollient, this duo deeply nourishes and reinforces the skin barrier.

  • Titanium Dioxide

    A skin-safe mineral used for its UV-absorbing and brightening properties. Titanium Dioxide helps protect the skin’s surface while enhancing a smooth, even-toned appearance.

What Makes Us Different

We are the most scientifically advanced Anti-Glycation End (A.G.E.) skincare brand with proprietary and patented ingredient Supplamine®.

Ophthalmologist-tested, non-irritating, and safe for use by contact lens wearers. It visibly improves puffiness, dark circles, and fine lines around the eyes.

MADE IN USA | FOUNDED BY SCIENTIST

Scientific Background

MEG 21 with Supplamine® was born from groundbreaking research by Dr. Annette M. Tobia, Ph.D., and the Fox Chase Cancer Center. Originally focused on finding treatments for diabetes-related complications, such as kidney disease, Dr. Tobia discovered that the same compounds used in those treatments could also prevent and treat visible signs of aging. After conducting seven independent trials, MEG 21 with Supplamine® was launched.

Since its debut in 1997, MEG 21 has been trusted by skincare professionals for over 20 years. Its efficacy is supported by nine clinical studies, including two focused on the eye area and one peer-reviewed study, all showcasing the transformative effects of our patented technology on skin health.

Learn More

MEG 21

Frequently Asked Questions

What is Supplamine®?

Supplamine® is a patented compound developed at Fox Chase Cancer Center. It targets glycation, inflammation, and oxidative stress — three major contributors to visible skin aging. Unlike typical skincare ingredients that mask symptoms, Supplamine® addresses aging at the cellular level.

How does Supplamine® work?

Supplamine® blocks toxic sugar byproducts (like 3DG) and helps prevent the formation of AGEs (Advanced Glycation End Products). This process helps protect collagen and elastin, improving skin firmness, clarity, and resilience over time.

What is glycation and why does it matter?

Glycation is a process where sugar molecules attach to proteins like collagen and elastin, making them stiff and damaged (called AGEs – Advanced Glycation End Products). This leads to sagging, wrinkles, and dullness — especially in the thin, delicate eye area. Supplamine® helps block these effects before they take hold.

What are AGEs and why do they matter for skin?

AGEs (Advanced Glycation End Products) form when sugars bind to skin proteins like collagen, making them stiff and less functional. AGEs are one of the biggest contributors to wrinkles, sagging, dullness, and skin thinning.

What does the Eye Treatment do?

MEG 21 Bright & Firm Eye Treatment is designed to reduce the appearance of fine lines, crow’s feet, puffiness, and dark circles. It soothes and hydrates the delicate under-eye area while improving firmness and skin tone.

Is this safe for sensitive skin or eyes?

Yes. This formula is ophthalmologist-tested, non-irritating, and safe for contact lens wearers. It's suitable even for sensitive or post-procedure skin.

Can I layer this with other skincare products?

Yes — MEG 21 Eye Treatment layers well with moisturizers, serums, and sunscreen. Always apply it before heavier creams and after cleansing.

When will I see results?

Some users report smoother, more hydrated skin within the first week. Visible improvements in firmness, puffiness, and fine lines are typically seen within 4–6 weeks with consistent use. Individual results may vary.

Customer Reviews

Based on 63 reviews
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D
Donba Schow
Effective Product

Gives me great protection from dry weather and sun. Easy to dispense. A little goes a long way. The fragrance is a bit strong.

C
CCreations63
This eye cream really does what it says

I have been using this eye cream for two weeks twice a day now. I have noticed that my under eyes are smoother and the fine lines are less visible. Most of all, my upper eyelids are no longer sagging and it feels lifted. Very promising product and will repurchase again.

H
Hanna
Meg 21

Meg 21 eye cream works wonders for the under eye area. It diminishes fine lines helps firm the skin and is a fabulous moisturizer.

L
Lynn Yanow
Awesome eye cream

Effective anti aging eye cream and can observe the firmness it has during the first application. Will continue to purchase.

B
Beatrice
Love it

Smooth and easy to absorb, I love the smell. Will keep using for longer.

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