Soothing treatment for redness-prone, sensitive skin

MEG 21 Soothe & Calm Redness Relief – 1 oz

  • Soothes Redness
  • Sensitive Skin
  • Supplamine®
  • Glycation Defense
$50.001.0 oz / 30 g

Calm the look of redness. Comfort sensitive skin. A targeted treatment formulated to soothe visibly red, reactive-looking skin while delivering MEG 21’s patented Supplamine® technology.

Physician-dispensed
Supplamine® anti-glycation technology


Cleanse skin thoroughly. Apply Redness Relief to affected areas twice daily. For external use only. Avoid contact with eyes. If contact occurs, rinse thoroughly with water.


Sensitive or redness-prone skin experiencing visible redness or discomfort. Also designed for skin needing soothing care following cosmetic procedures.

Water, Butylene Glycol, Arginine HCl, Methylglucamine HCl, Aluminum Starch Octenyl Succinate, Crosspolymer, Lecithin, Sodium Hydroxide, Leuconostoc/Radish Root Ferment Filtrate, Aloe Barbadensis Leaf Juice, Carbomer, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Chlorphenesin, Propylene Glycol, Symphytum Officinale Root Extract, Arctium Majus Root Extract, Ammonium Glycyrrhizate, Allantoin, Bisabolol, Zingiber Officinale (Ginger) Root Extract, Disodium EDTA

Pair it with these for a full morning-to-night routine.

How it works in the skin

Supplamine® is the heart of every MEG 21 formula, this original one included. It helps interrupt glycation early, where sugars bond to collagen and elastin.

  • Supplamine® at the coreOur signature anti-glycation complex.
  • The original formulaThe MEG 21 customers have used for years.
Explore the science
Our anti-glycation complex intercepting sugar by-products above collagen fibresSupplamine®Our anti-glycation technologyHelps interrupt glycation early, when sugars bond to collagen and elastin.Learn more

Images are for illustration purposes only.

Trusted by physicians

Developed by Dr. Annette Tobia, PhD, and dispensed by physicians who trust it with their patients.

  • Physician-dispensedOffered in medical practices.
  • Complements your treatmentsUse between visits, once your provider says your skin is ready.
For professionals
Dr. Betsy A.B. Greenleaf, DO
Dr. Betsy A.B. Greenleaf, DOFACOOG, FACOG, FPMRS, FAAOPM, MBA
I was dazzled by the science but fell in love with how great it works. This has been my go-to product for myself, my family, and my patients.
Dr. Adrian Manjarrez-Cortez, MD
Dr. Adrian Manjarrez-Cortez, MDPlastic Surgery
MEG 21 offers effective moisturization, addresses skin firmness and reduces fine lines and wrinkles…
Dr. Kenneth Redcross, MD
Dr. Kenneth Redcross, MDInternal Medicine
What I love about MEG 21 is that it actually works — thanks to Supplamine®, their powerful, science-backed secret weapon.
Dr. Alice McKee, MD
Dr. Alice McKee, MDFamily Medicine
When I recommend MEG 21, I speak from both science and personal experience. It makes skin supple — less wrinkled, less dry, less 'hard.'

Try MEG 21 with the Discovery Kit

Five travel sizes of the MEG 21 anti-glycation range in a custom cosmetic bag: the serum, two treatments, the eye treatment and the mineral SPF. The whole routine, before you commit to full sizes.

Shop the Discovery Kit — $30