Daily Anti-Glycation Face Cream

Supplamine® Smooth Radiance Face Treatment Cream

  • Supplamine®
  • Hydrating
  • Soothing
  • All Skin Types
$130.001.7 oz / 50 g
4.8 60 reviews

Face Treatment is one of our hero products, powered by Supplamine® — a patented ingredient shown in clinical studies to visibly reduce the appearance of fine lines and wrinkles in just 28 days. This formula helps neutralize glycation, oxidative stress, and inflammation — three key factors that accelerate skin aging. It also hydrates, soothes, and supports firmer, more radiant-looking skin, while helping protect against environmental stressors.

(1.7 oz / 50 g) - Suitable for all skin types

Physician-dispensed
Supplamine® anti-glycation technology

Morning and night, smooth a small amount over clean face and neck.

In the morning, finish with Daily Mineral Shield SPF 30. This cream offers no sun protection.

All skin types.

For anyone who wants skin that feels hydrated and soothed, and looks smoother, firmer and more radiant, with Supplamine® in every jar.

Water, Lecithin, Propylene Glycol, Isopropyl Myristate, Behenyl Alcohol, Cyclopentasiloxane, Theobroma Cacao Seed Butter, Ceteareth-20, Arginine HCl, Cyclohexasiloxane, Hydrogenated Jojoba Oil, Methylglucamine HCl, Polysorbate 80, Polyacrylamide, Alcohol, Glyceryl Stearate Se, Acacia Senegal Gum, Aloe Barbadensis Leaf Extract, Bisabolol, Dimethicone, Oenothera Biennis Oil, Olive Oil PEG-7 Esters, Squalane, Tocopherol, Tocopheryl Acetate, C13-14 Isoparaffin, Parfum, Laureth-7, Acetylated Lanolin Alcohol, Cetyl Acetate, Disodium EDTA, Tetrasodium EDTA, Diazolidinyl Urea, Phenoxyethanol, Methylparaben, Butylparaben, Ethylparaben, Propylparaben, Iodopropynyl Butylcarbamate, Benzyl Benzoate, Benzyl Salicylate, Butylphenyl Methylpropional, Hexyl Cinnamal, Hydroxycitronellal, Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde, Linalool

Pair it with these for a full morning-to-night routine.

Results you can see, and measure

Every participant's skin was compared with its own starting point, so the change you see is the change that happened.

  • Measured by instrumentsHydration, firmness and lines tracked at 8 weeks.
  • Your skin vs. its own startEach result compares skin with its baseline.
  • The original formulaThis is the formula the study used.
Explore the science
+62.9%Skin hydrationat 8 weeks · Instrumental measurement
+35.4%Skin firmnessat 8 weeks · Measured by ballistometry
−44.2%Area of lines & wrinklesat 8 weeks · Image analysis of skin replicas
−50.5%Superficial facial linesat 8 weeks · Expert grading

In an 8-week open-label study of an original MEG 21 Supplamine® formula, conducted by a contract research organisation.

Individual results may vary.

How it works in the skin

Supplamine® is the heart of every MEG 21 formula, this original one included. It helps interrupt glycation early, where sugars bond to collagen and elastin.

  • Supplamine® at the coreOur signature anti-glycation complex.
  • The original formulaThe MEG 21 customers have used for years.
Explore the science
Our anti-glycation complex intercepting sugar by-products above collagen fibresSupplamine®Our anti-glycation technologyHelps interrupt glycation early, when sugars bond to collagen and elastin.Learn more

Images are for illustration purposes only.

Try the new formula

MEG 21 Smooth Radiance Face Treatment jar on a lilac background

New formula

Smooth Radiance Face Treatment

The same MEG 21 science, updated in our newest formula.

$130.00

View

Trusted by physicians

Developed by Dr. Annette Tobia, PhD, and dispensed by physicians who trust it with their patients.

  • Physician-dispensedOffered in medical practices.
  • Complements your treatmentsUse between visits, once your provider says your skin is ready.
For professionals
Dr. Betsy A.B. Greenleaf, DO
Dr. Betsy A.B. Greenleaf, DOFACOOG, FACOG, FPMRS, FAAOPM, MBA
I was dazzled by the science but fell in love with how great it works. This has been my go-to product for myself, my family, and my patients.
Dr. Adrian Manjarrez-Cortez, MD
Dr. Adrian Manjarrez-Cortez, MDPlastic Surgery
MEG 21 offers effective moisturization, addresses skin firmness and reduces fine lines and wrinkles…
Dr. Kenneth Redcross, MD
Dr. Kenneth Redcross, MDInternal Medicine
What I love about MEG 21 is that it actually works — thanks to Supplamine®, their powerful, science-backed secret weapon.
Dr. Alice McKee, MD
Dr. Alice McKee, MDFamily Medicine
When I recommend MEG 21, I speak from both science and personal experience. It makes skin supple — less wrinkled, less dry, less 'hard.'

Try MEG 21 with the Discovery Kit

Five travel sizes of the MEG 21 anti-glycation range in a custom cosmetic bag: the serum, two treatments, the eye treatment and the mineral SPF. The whole routine, before you commit to full sizes.

Shop the Discovery Kit — $30